The Therapeutic Potential of Vitamins B1, B3 and B6 in Charcot–Marie–Tooth Disease with the Compromised Status of Vitamin-Dependent Processes

Understanding the molecular mechanisms of neurological disorders is necessary for development personalized medicine. When diagnosis considers not only disease symptoms, but also their basis, treatments tailored to individual patients may be suggested. Vitamin-responsive are induced by deficiencies in vitamin-dependent processes. These occur due genetic impairments proteins whose functions involved with vitamins. This review enzymes encoded DHTKD1, PDK3 and PDXK genes, mutations observed Charcot–Marie–Tooth (CMT) disease. The bind or produce coenzyme forms vitamins B1 (thiamine diphosphate, ThDP) B6 (pyridoxal-5′-phosphate, PLP). Alleviation such through administration lacking vitamin its derivative calls a better introduction mechanistic knowledge medical diagnostics therapies. Recent data on lower levels B3 derivative, NAD+, blood CMT vs. control subjects considered view NAD-dependent pathological axonal degeneration, suggesting therapeutic potential these patients. Thus, improved underlying causes allow vitamin-responsive benefit from B1, B3, B6, natural derivatives, pharmacological forms.